There are many engineering tools used for device and packaging development. Some tools that pintegriti develops and has experience with are listed. Please contact us for further explanation and the use of tools.

Autoinjector Dosing Model

  • Inputs: spring modulus (or loads at two different lengths), dimensions of syringe barrel and needle, product volume, density and viscosity, plunger/spring frictions, air gap
  • Outputs: dosing time, delivered volume, forces balance between spring, friction and hydraulic forces
  • Software: Visual Basic in Excel (Macro) or Mathcad developed by pintegriti
  • Applications: dosing time from different spring forces, product volumes & viscosity, size of syringe barrels & needles

Moisture Prediction Modeling (MPM)

  • Inputs: product (or/and desiccant) moisture sorption isotherm, weight, package permeability, size/volume, environment temperature and humidity
  • Outputs: moisture content (or water activity) of product overtime
  • Software: Visual Basic in Excel (Macro) developed by pintegriti
  • Applications: packaging design, material selection, determine the amount of desiccant, determine the shelf life with a critical moisture content

Oxygen Transmission Rate (OxTR) calculation

  • Inputs: O2 concentrations at various time points, volume of container, O2 concentration at storage
  • Outputs: Oxygen Transmission Rate (OxTR), O2 inside of container as a function of time
  • Software: Visual Basic in Excel (Macro) developed by pintegriti
  • Applications: quantify the barrier property of O2, verify CCI with O2 transmission rate

Mean Kinetic Temperature (MKT) calculation

  • Inputs: collected temperatures with time
  • Outputs: calculated MKT and arithmetic mean temperature, a chart showing collected temperatures as a function of time
  • Software: Visual Basic in Excel (Macro) developed by pintegriti
  • Applications: to understand the temperature impact on the product kinetic, justify temperature excursion

Product-Packaging Stability Modeling

  • Inputs: product kinetic model (a relationship between product degradation rate , temperature and RH), inputs from MPM (Note: if the product is sensitive to oxygen, the calculation needs to include a product kinetic model for oxygen and OxTR)
  • Outputs: potency and impurity change of product in a container as a function of time
  • Software: Visual Basic in Excel (Macro) developed by pintegriti
  • Applications: container material selection and design, product process development (e.g., initial moisture content), risk management for failure modes

Tolerance Stack-up Analysis

  • Inputs: dimensions of components, acceptable gap or interference fit
  • Outputs: failures per million
  • Software: Excel developed by pintegriti
  • Applications: container components and system qualification, device design verification, evaluation of manufacturing capability

Finite Element Analysis (FEA)

  • Inputs: CAD of components, stress-strain model
  • Outputs: stress and strain of components
  • Software: Ansys, Abaqus
  • Applications: stress and strain analysis for rubber seal integrity, component-component stress in interference fit, device design verification, force calculation, stress concentration

Heat Transfer FEA

  • Inputs: CAD of components, thermal properties like thermal conductivity for steady-state analysis and specific heat, density for transient heat transfer analysis
  • Outputs: temperature change as a function of time, time to reach steady-state
  • Software: Ansys, Abaqus
  • Applications: temperature impact on product (e.g., heat sealing process), cold chain shipper design, refrigerated product equilibrium time at ambient

Space utilization

  • Inputs: dimensions of product and carton
  • Outputs: carton size and product size for the maximum load, pallet patterns layout
  • Software: TOPS, CAPE
  • Applications: to design carton and shipper, optimize a shipping